Apoptosis in cancer

Lowe, S. W., Lin, A. W. (March 2000) Apoptosis in cancer. Carcinogenesis, 21 (3). pp. 485-495. ISSN 0143-3334

URL: http://www.ncbi.nlm.nih.gov/pubmed/10688869
DOI: 10.1093/carcin/21.3.485

Abstract

In the last decade, basic cancer research has produced remarkable advances in our understanding of cancer biology and cancer genetics, Among the most important of these advances is the realization that apoptosis and the genes that control it have a profound effect on the malignant phenotype. For example, it is now clear that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or metastasis. Conversely, compelling evidence indicates that other oncogenic changes promote apoptosis, thereby producing selective pressure to override apoptosis during multistage carcinogenesis. Finally, it is now well documented that most cytotoxic anticancer agents induce apoptosis, raising the intriguing possibility that defects in apoptotic programs contribute to treatment failure, Because the same mutations that suppress apoptosis during tumor development also reduce treatment sensitivity, apoptosis provides a conceptual framework to link cancer genetics with cancer therapy. An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the nest decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.

Item Type: Paper
Uncontrolled Keywords: PROGRAMMED CELL-DEATH WILD-TYPE P53 CHEMOTHERAPY-INDUCED APOPTOSIS MYC-INDUCED APOPTOSIS ONCOGENE-DEPENDENT APOPTOSIS RADIATION-INDUCED APOPTOSIS MYELOID LEUKEMIC-CELLS S-PHASE ENTRY C-MYC TUMOR-SUPPRESSOR
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: March 2000
Date Deposited: 31 Jan 2014 20:40
Last Modified: 31 Jan 2014 20:40
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29352

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