Acute stress induced modifications of calcium signaling in learned helpless rats

Velbinger, K., De Vry, J., Jentzsch, K., Eckert, A., Henn, F., Muller, W. E. (July 2000) Acute stress induced modifications of calcium signaling in learned helpless rats. Pharmacopsychiatry, 33 (4). pp. 132-7. ISSN 0176-3679 (Print)0176-3679 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10958261
DOI: 10.1055/s-2000-11220

Abstract

Previous reports have demonstrated reduced elevations of free intracellular calcium concentration in blood cells of depressed patients after various stimuli. Therefore, a disturbance of intracellular calcium (Ca2+) homeostasis has been postulated to be involved in the pathophysiology of mood disorders. It was the aim of the present study to investigate whether Ca2+ signaling was affected in spleen T-lymphocytes of rats submitted to a learned helplessness paradigm, an animal model of depression with a high level of construct, face and predictive validity. In addition, we tested for effects of acute stress on the Ca2+ signaling in helpless rats, as compared to non-stressed rats. It was found that mitogen-induced Ca2+ signaling only tended to be reduced in helpless rats. However, when helpless rats were submitted to acute immobilization stress, Ca2+ signaling appeared to be significantly blunted, whereas the same stressor did not affect Ca2+ signaling in the non-helpless control rats. These acute stress-induced differences in Ca2+ signaling were not paralleled by a differential increase in plasma corticosterone. It is hypothesized that blunted Ca2+ signaling, as assessed in spleen T-lymphocytes of helpless rats, may be a correlate of the increased vulnerability of helpless rats to acute stressors.

Item Type: Paper
Uncontrolled Keywords: Animals Avoidance Learning/ physiology Calcium Signaling/ physiology Corticosterone/blood Electroshock Helplessness, Learned Male Rats Rats, Wistar Spleen/immunology Stress, Psychological/ physiopathology T-Lymphocytes/ physiology
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: July 2000
Date Deposited: 31 Jan 2014 20:30
Last Modified: 31 Jan 2014 20:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29347

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