Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease

Thome, J., Retz, W., Baader, M., Pesold, B., Hu, M., Cowen, M., Durany, N., Adler, G., Henn, F. A., Rosler, M. (2001) Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease. J Neural Transm, 108 (10). pp. 1175-80. ISSN 0300-9564 (Print)0300-9564 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11725820
DOI: 10.1007/s007020170007

Abstract

In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (-1438G/A). Although there was a tendency toward an increased number of the genotype TT of the 5-HT6 receptor polymorphism in AD patients when compared to controls (2.8% vs. 1.3%), neither this nor the 5-HT2A promoter polymorphism showed significant differences in their genotypic or allelic distribution among patients and controls. These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD.

Item Type: Paper
Uncontrolled Keywords: Alleles Alzheimer Disease/ genetics Chi-Square Distribution Genetic Variation/genetics Genotype Humans Polymorphism, Genetic/ genetics Promoter Regions, Genetic/genetics Receptor, Serotonin, 5-HT2A Receptors, Serotonin/ genetics
Subjects: diseases & disorders > mental disorders > delirium dementia cognitive disorders > Alzheimer's disease
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > single nucleotide polymorphism
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 2001
Date Deposited: 16 Jan 2014 15:39
Last Modified: 16 Jan 2014 15:39
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29320

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