Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus

Thome, J., Pesold, B., Baader, M., Hu, M., Gewirtz, J. C., Duman, R. S., Henn, F. A. (2001) Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus. Biol Psychiatry, 50 (10). pp. 809-12. ISSN 0006-3223 (Print)0006-3223 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11720700
DOI: 10.1016/S0006-3223(01)01229-X

Abstract

BACKGROUND: In view of the effects of stress on synaptic plasticity, the regulation of synaptophysin and synaptotagmin expression by immobilization was analyzed by in situ hybridization. METHODS: Rats were exposed to immobilization stress, which induced typical behavioral alterations, such as reduced locomotor activity after stress exposure. Determination of mRNA levels of the integral synaptic vesicle proteins was performed immediately after acute or chronic immobilization. RESULTS: The results demonstrate that stress exposure leads to reduced expression of synaptophysin but increased expression of synaptotagmin in the hippocampus. CONCLUSIONS: This rapid and differential regulation of synaptic vesicle proteins could be responsible for some of the morphological, biochemical, and behavioral changes observed after stress exposure. These changes may be relevant to such clinical disorders as psychoses, depression, and posttraumatic stress disorder that are sensitive to stress and involve changes in neural and synaptic plasticity.

Item Type: Paper
Uncontrolled Keywords: Animals Calcium-Binding Proteins Gene Expression Regulation/physiology Hippocampus/ pathology Membrane Glycoproteins/ genetics Nerve Tissue Proteins/ genetics Neuronal Plasticity/genetics RNA, Messenger/genetics Rats Rats, Sprague-Dawley Restraint, Physical Stress, Psychological/ complications/pathology Synaptophysin/ genetics Synaptotagmins
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
organs, tissues, organelles, cell types and functions > tissues types and functions > synaptogenesis
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date Deposited: 16 Jan 2014 15:33
Last Modified: 16 Jan 2014 15:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29319

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