Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo

Stern, E. A., Maravall, M., Svoboda, K. (August 2001) Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo. Neuron, 31 (2). pp. 305-315. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/11502260
DOI: 10.1016/S0896-6273(01)00360-9

Abstract

Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. At P12, synaptic responses were undetectable. Only 2 days later in life (P14), receptive fields had mature organization. Sensory deprivation, if initiated before P14, disrupted receptive field structure. In layer 4, responses and maps were already mature by P12 and insensitive to deprivation, implying that barrel cortex develops from layer 4 to layer 2/3. Thus, P12-14 is a critical period shared by layer 2/3 synapses and their spines, suggesting that spine plasticity is involved in the refinement of maps.

Item Type: Paper
Uncontrolled Keywords: EXPERIENCE-DEPENDENT PLASTICITY NEOCORTICAL PYRAMIDAL NEURONS CAT VISUAL-CORTEX SOMATOSENSORY CORTEX IN-VIVO CRITICAL PERIOD SYNAPTIC ACTIVITY THALAMOCORTICAL SYNAPSES COLUMNAR ORGANIZATION POSTNATAL-DEVELOPMENT
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > barrel cortex
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Matt Covey
Date: August 2001
Date Deposited: 15 Jan 2014 21:24
Last Modified: 15 Jan 2014 21:24
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29311

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