Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

Shi, S. H., Hayashi, Y., Esteban, J. A., Malinow, R. (May 2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell, 105 (3). pp. 331-343. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/11348590
DOI: 10.1016/S0092-8674(01)00321-X

Abstract

AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are heterooligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/ GluR2 receptors are added to synapses during plasticity; this requires interactions between GluR1 and group I PDZ domain proteins. In contrast, GluR2/GluR3 receptors replace existing synaptic receptors continuously; this occurs only at synapses that already have AMPA-Rs and requires interactions by GluR2 with NSF and group I! PDZ domain proteins. The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION DOMAIN-CONTAINING PROTEIN MEDIATED GENE-TRANSFER SYNAPTIC PLASTICITY GLUTAMATE RECEPTORS SILENT SYNAPSES POSTSYNAPTIC EXPRESSION BRAIN-SLICES PDZ DOMAINS LTP
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: May 2001
Date Deposited: 16 Jan 2014 16:57
Last Modified: 16 Jan 2014 16:57
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29304

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