Cytoskeletal changes in cell transformation and tumorigenesis

Pawlak, G., Helfman, D. M. (2001) Cytoskeletal changes in cell transformation and tumorigenesis. Current Opinion in Genetics & Development, 11 (1). pp. 41-47. ISSN 0959-437X

URL: http://www.ncbi.nlm.nih.gov/pubmed/11163149
DOI: 10.1016/S0959-437X(00)00154-4

Abstract

Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.

Item Type: Paper
Uncontrolled Keywords: FOCAL ADHESION KINASE TYPE-2 GENE-PRODUCT SIGNAL-TRANSDUCTION SMOOTH-MUSCLE NONMUSCLE TROPOMYOSIN EXTRACELLULAR-MATRIX TYROSINE KINASE RHO-GTPASES 3T3 CELLS EXPRESSION
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > cytoskeletal proteins
CSHL Authors:
Communities: CSHL labs > Helfman lab
Depositing User: Matt Covey
Date Deposited: 17 Jan 2014 20:49
Last Modified: 17 Jan 2014 20:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29283

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