Developmental regulation of CPG15 expression in Xenopus

Nedivi, E., Javaherian, A., Cantallops, I., Cline, H. T. (July 2001) Developmental regulation of CPG15 expression in Xenopus. Journal of Comparative Neurology, 435 (4). pp. 464-473. ISSN 0021-9967

URL: http://www.ncbi.nlm.nih.gov/pubmed/11406826
DOI: 10.1002/cne.1044

Abstract

Mechanisms controlling dendritic arbor formation affect the establishment of neuronal circuits. Candidate plasticity gene 15 (CPG15) is a glycosylphosphatidyl inositol (GPI)-linked activity-induced protein that has been shown to function as an intercellular signaling molecule that can promote the morphological and physiological development of the Xenopus retinotectal system. A thorough understanding of CPG15 function requires knowledge of the spatiotemporal expression of the endogenous protein. We therefore cloned Xenopus cpg15 and used RNA in situ hybridization and immunohistochemistry to determine the pattern of CPG15 expression. cpg15 mRNA and CPG15 protein are first detectable in the developing spinal cord and become widespread as development proceeds. CPG15 is expressed in sensory regions of the brain, including the visual, auditory, and olfactory systems. Within the retina, CPG15 is only expressed in retinal ganglion cells. CPG15 protein is concentrated in axon tracts, including retinal axons. These data support a model in which CPG15 expressed in retinal ganglion cells is trafficked to retinal axone, where it modulates postsynaptic dendritic arbor elaboration, and synaptic maturation.

Item Type: Paper
Uncontrolled Keywords: neuritin ligand retinotectal GPI spinal cord amphibian plasticity visual system LONG-TERM POTENTIATION IMMUNOGLOBULIN SUPERFAMILY GABA IMMUNOREACTIVITY NEURITE OUTGROWTH NEURAL ACTIVITY VISUAL-SYSTEM GROWTH-FACTOR OPTIC TECTUM PROTEIN GENE
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organism description > animal behavior > visual
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: July 2001
Date Deposited: 17 Jan 2014 20:31
Last Modified: 17 Jan 2014 20:31
PMCID: PMC3070489
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29276

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