Shaping the metaphase chromosome: coordination of cohesion and condensation

Losada, A., Hirano, T. (October 2001) Shaping the metaphase chromosome: coordination of cohesion and condensation. Bioessays, 23 (10). pp. 924-935. ISSN 0265-9247

URL: http://www.ncbi.nlm.nih.gov/pubmed/11598959
DOI: 10.1002/bies.1133

Abstract

Recent progress in our understanding of mitotic chromosome dynamics has been accelerated by the identification of two essential protein complexes, cohesin and condensin. Cohesin is required for holding sister chromatids (duplicated chromosomes) together from S phase until the metaphase-to-anaphase transition. Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of this review is to discuss how the mitotic metaphase chromosome is assembled and shaped by a precise balance between the cohesion and condensation machineries. We argue that, in different eukaryotic organisms, the balance of cohesion and condensation is adjusted in such a way that the size and shape of the resulting chromosomes are best suited for their accurate segregation.

Item Type: Paper
Uncontrolled Keywords: SISTER-CHROMATID COHESION BUDDING YEAST SACCHAROMYCES-CEREVISIAE PROTEIN COMPLEXES DNA-REPLICATION 13S CONDENSIN HISTONE H3 STRUCTURAL MAINTENANCE PRECOCIOUS SEPARATION CONSERVED PROTEIN
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > metaphase
CSHL Authors:
Communities: CSHL labs > Hirano lab
Depositing User: Matt Covey
Date: October 2001
Date Deposited: 17 Jan 2014 21:38
Last Modified: 17 Jan 2014 21:38
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29266

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