An unusual population of pyramidal neurons in the anterior cingulate cortex of hominids contains the calcium-binding protein calretinin

Hof, P. R., Nimchinsky, E. A., Perl, D. P., Erwin, J. M. (July 2001) An unusual population of pyramidal neurons in the anterior cingulate cortex of hominids contains the calcium-binding protein calretinin. Neuroscience Letters, 307 (3). pp. 139-142. ISSN 0304-3940

URL: http://www.ncbi.nlm.nih.gov/pubmed/11438383
DOI: 10.1016/S0304-3940(01)01964-4

Abstract

In the context of an on-going comparative analysis of primate neocortex evolution, we describe the occurrence and distribution of a previously unrecognized group of pyramidal neurons, restricted to the superficial part of layer V in the anterior cingulate cortex of hominids and characterized by immunoreactivity to the calcium-binding protein, calretinin. These neurons were rare in orangutans, more numerous in gorillas and common chimpanzees, while humans had the highest numbers. These calretinin-containing pyramidal cells were not observed in the cingulate cortex of any other primate or mammalian species. This finding, together with other recent observations on the hominoid cingulate cortex, is interesting when considering primate neocortical evolution, as it indicates possible adaptive and anatomical modifications in a cortical region critical for the integration of many aspects of autonomic function, vocalization, and cognitive processes.

Item Type: Paper
Uncontrolled Keywords: brain evolution calcium-binding proteins cingulate cortex great apes neocortex primates pyramidal neurons PREFRONTAL CORTICAL PROJECTIONS DIFFERENTIAL VULNERABILITY SOMATOSENSORY CORTEX MACAQUE MONKEYS PARVALBUMIN NEOCORTEX CALBINDIN PRIMATES CELLS BRAIN
Subjects: organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organism description > animal > mammal > primates
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Matt Covey
Date: July 2001
Date Deposited: 21 Jan 2014 16:57
Last Modified: 21 Jan 2014 16:57
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29252

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