Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans

Hoeppner, D. J., Hengartner, M. O., Schnabel, R. (July 2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature, 412 (6843). pp. 202-206. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/11449279
DOI: 10.1038/35084103

Abstract

Genetic studies have identified over a dozen genes that function in programmed cell death (apoptosis) in the nematode Caenorhabditis elegans(1-3). Although the ultimate effects on cell survival or engulfment of mutations in each cell death gene have been extensively described, much less is known about how these mutations affect the kinetics of death and engulfment, or the interactions between these two processes. We have used four-dimensional-Nomarski time-lapse video microscopy to follow in detail how cell death genes regulate the extent and kinetics of apoptotic cell death and removal in the early C. elegans embryo. Here we show that blocking engulfment enhances cell survival when cells are subjected to weak pro-apoptotic signals. Thus, genes that mediate corpse removal can also function to actively kill cells.

Item Type: Paper
Uncontrolled Keywords: C-ELEGANS APOPTOSIS PROTEIN GENETICS NEMATODE CORPSES
Subjects: organism description > animal > C elegans
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Matt Covey
Date: July 2001
Date Deposited: 21 Jan 2014 16:28
Last Modified: 21 Jan 2014 16:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29251

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving