A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

Hendricks, J. C., Williams, J. A., Panckeri, K., Kirk, D., Tello, M., Yin, J. C. P., Sehgal, A. (November 2001) A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nature Neuroscience, 4 (11). pp. 1108-1115. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11687816
DOI: 10.1038/nn743

Abstract

In the fruit fly, Drosophila melanogaster, rest shares features with mammalian sleep, including prolonged immobility, decreased sensory responsiveness and a homeostatic rebound after deprivation. To understand the molecular regulation of sleep-like rest, we investigated the involvement of a candidate gene, cAMP response-element binding protein (CREB). The duration of rest was inversely related to cAMP signaling and CREB activity. Acutely blocking CREB activity in transgenic flies did not affect the clock, but increased rest rebound. CREB mutants also had a prolonged and increased homeostatic rebound. In wild types, in vivo CREB activity increased after rest deprivation and remained elevated for a 72-hour recovery period. These data indicate that cAMP signaling has a non-circadian role in waking and rest homeostasis in Drosophila.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM-MEMORY GENE-EXPRESSION SLEEP ANTIDEPRESSANT INDUCTION INCREASES ACTIVATOR WAKING CLOCK STATE
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > REM sleep
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
CSHL Authors:
Communities: CSHL labs > Yin lab
Depositing User: Matt Covey
Date: November 2001
Date Deposited: 17 Jan 2014 21:48
Last Modified: 17 Jan 2014 21:48
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29244

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