Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)

Giese, K. P., Friedman, E., Telliez, J. B., Fedorov, N. B., Wines, M., Feig, L. A., Silva, A. J. (November 2001) Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology, 41 (6). pp. 791-800. ISSN 0028-3908

URL: http://www.ncbi.nlm.nih.gov/pubmed/11640934
DOI: 10.1016/S0028-3908(01)00096-X

Abstract

Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory. (C) 2001 Elsevier Science Ltd. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: amygdala gene targeting hippocampus learning mutant mouse Ras signaling LONG-TERM-MEMORY PROTEIN-MEDIATED SIGNALS EXCHANGE FACTOR DORSAL HIPPOCAMPUS KINASE CASCADE IMPRINTED GENE ACTIVATION FEAR LESIONS GRF
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > learning
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: November 2001
Date Deposited: 22 Jan 2014 17:58
Last Modified: 22 Jan 2014 17:58
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29238

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