The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo

Foa, L., Rajan, I., Haas, K., Wu, G. Y., Brakeman, P., Worley, P., Cline, H. (May 2001) The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo. Nature Neuroscience, 4 (5). pp. 499-506. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11319558
DOI: 10.1038/87447

Abstract

Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.

Item Type: Paper
Uncontrolled Keywords: METABOTROPIC GLUTAMATE RECEPTORS GROWTH CONES GRANULE CELLS SMALL GTPASES CALCIUM GUIDANCE FAMILY CYTOSKELETON DROSOPHILA MOLECULES
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: May 2001
Date Deposited: 22 Jan 2014 17:24
Last Modified: 22 Jan 2014 17:24
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29233

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving