Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Neesse, A., Krug, S., Gress, T. M., Tuveson, D. A., Michl, P. (2013) Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma. Onco Targets Ther, 7. pp. 33-43. ISSN 1178-6930 (Print)1178-6930

[img]
Preview
PDF (Paper)
Tuveson OncoTargets and therapy 2013.pdf - Published Version

Download (675Kb) | Preview
URL: http://www.ncbi.nlm.nih.gov/pubmed/24379681
DOI: 10.2147/ott.s38111

Abstract

Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment.

Item Type: Paper
Subjects: diseases & disorders > cancer
therapies > cancer drugs - see diseases-cancer-drugs and therapies
diseases & disorders > cancer > drugs and therapies > chemoresistance
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date Deposited: 07 Jan 2014 20:26
Last Modified: 07 Jan 2014 20:26
PMCID: PMC3872146
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29207

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving