DNA methylation in eukaryotes

Martienssen, R. A., Richards, E. J. (1995) DNA methylation in eukaryotes. Current Opinion in Genetics and Development, 5 (2). pp. 234-242. ISSN 0959437X (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7613094
DOI: 10.1016/0959-437X(95)80014-X

Abstract

Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation mutants in mice, Neurospora, and Arabadopsis will allow traditional genetic dissection to be applied to long-standing problems regarding the function and regulation of eukaryotic DNA methylation. Although methylation appears to be important for maintenance of different epigenetic states, the mechanism that establishes these states is likely to involve additional processes.

Item Type: Paper
Uncontrolled Keywords: Animals DNA Eukaryotic Cells Gene Expression Regulation Humans Methylation Mutation Plants
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date Deposited: 07 Jan 2014 15:12
Last Modified: 07 Jan 2014 15:12
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29192

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