Nitric oxide and Drosophila development

Enikolopov, G., Banerji, J., Kuzin, B. (October 1999) Nitric oxide and Drosophila development. Cell Death and Differentiation, 6 (10). pp. 956-963. ISSN 1350-9047

URL: http://www.ncbi.nlm.nih.gov/pubmed/10556972
DOI: 10.1038/sj.cdd.4400577

Abstract

Mechanisms controlling the transition of precursor cells from proliferation to differentiation during organism development determine the distinct anatomical features of tissues anti organs. NO may mediate such a transition since it can suppress DNA synthesis and cell proliferation, inhibition of NOS activity in the imaginal discs of Drosophila larvae results in hypertrophy of tissues and organs of the adult fly, whereas ectopic overexpression of NOS has the reciprocal, hypotrophic, effect. Furthermore, NO production is crucial for the establishment of ordered neuronal connections in the visual system of the fly, indicating that NO affects the acquisition of the differentiated phenotype by the neural tissue, Increasing evidence points to a broad role that NO may play in animal development by acting as an essential negative regulator of precursor cell proliferation during tissue and organ morphogenesis.

Item Type: Paper
Uncontrolled Keywords: nitric oxide drosophila differentiation synaptogenesis organ development SMOOTH-MUSCLE CELLS NERVOUS-SYSTEM PC12 CELLS INDUCED APOPTOSIS NADPH-DIAPHORASE NEURONAL CELLS VISUAL-SYSTEM GROWTH-FACTOR NO-SYNTHASE IN-VITRO
Subjects: organism description > animal > insect > Drosophila
organism description > animal > developmental stage
bioinformatics > genomics and proteomics > small molecules > nitric oxide
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: Matt Covey
Date: October 1999
Date Deposited: 20 Dec 2013 15:55
Last Modified: 20 Dec 2013 15:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29138

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