Precise olfactory responses tile the sniff cycle

Shusterman, R., Smear, M. C., Koulakov, A. A., Rinberg, D. (2011) Precise olfactory responses tile the sniff cycle. Nature Neuroscience, 14 (8). 1039-U136. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/21765422
DOI: 10.1038/nn.2877

Abstract

In terrestrial vertebrates, sniffing controls odorant access to receptors, and therefore sets the timescale of olfactory stimuli. We found that odorants evoked precisely sniff-locked activity in mitral/tufted cells in the olfactory bulb of awake mouse. The trial-to-trial response jitter averaged 12 ms, a precision comparable to other sensory systems. Individual cells expressed odor-specific temporal patterns of activity and, across the population, onset times tiled the duration of the sniff cycle. Responses were more tightly time-locked to the sniff phase than to the time after inhalation onset. The spikes of single neurons carried sufficient information to discriminate odors. In addition, precise locking to sniff phase may facilitate ensemble coding by making synchrony relationships across neurons robust to variation in sniff rate. The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas.

Item Type: Paper
Uncontrolled Keywords: BULB UNIT-ACTIVITY ODOR REPRESENTATIONS TEMPORAL PRECISION SPIKE TRAINS TUFTED CELLS CORTEX RAT INFORMATION INHIBITION ACCURACY
Subjects: Investigative techniques and equipment > electrophysiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Koulakov lab
Depositing User: Matt Covey
Date Deposited: 19 Dec 2013 19:45
Last Modified: 19 Dec 2013 19:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29122

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