Rho GTPases: Signaling, migration, and invasion

Schmitz, A. A. P., Govek, E. E., Bottner, B., Van Aelst, L. (November 2000) Rho GTPases: Signaling, migration, and invasion. Experimental Cell Research, 261 (1). pp. 1-12. ISSN 0014-4827

URL: http://www.ncbi.nlm.nih.gov/pubmed/11082269
DOI: 10.1006/excr.2000.5049

Abstract

The acquisition of a motile and invasive phenotype is an important step in the development of tumors and ultimately metastasis. This step requires the abrogation of cell-cell contacts, the remodeling of the extracellular matrix and of cell-matrix interactions, and finally the movement of the cell mediated by the actin cytoskeleton. Evidence for participation of Rho GTPases in migration and invasion is addressed in this review with emphasis on epithelial cells and the contribution of Rho GTPases toward tumor invasion. The Rho GTPases, including Rac, Cdc42, and Rho, have been implicated in the establishment of cell-cell contacts and of cell-matrix interactions crucial to attaining a fully polarized epithelial state, and they are known for their regulation of the actin cytoskeleton and transcriptional activation. Under aberrant conditions, however, they have been implicated in motility, invasion, and some aspects of metastasis. It is well known that Rho GTPases are activated by different classes of transmembrane receptors and that they transmit these signals to their effector proteins. These downstream targets include not only adaptor proteins and kinases which affect the actin cytoskeleton, but also transcription factors leading to expression of genes necessary for the drastic morphological changes which accompany these processes. (C) 2000 Academic Press.

Item Type: Paper
Uncontrolled Keywords: Rho GTPases signaling motility actin cytoskeleton invasion CELL-CELL ADHESION WISKOTT-ALDRICH-SYNDROME SERUM RESPONSE FACTOR BINDING PROTEIN-RHO ACTIN-DEPOLYMERIZING PROTEIN MYOTONIC-DYSTROPHY KINASE ARP2/3 COMPLEX MYOSIN PHOSPHATASE EPITHELIAL-CELLS FAMILY GTPASES
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Van Aelst lab
Depositing User: Matt Covey
Date: November 2000
Date Deposited: 18 Dec 2013 21:35
Last Modified: 18 Dec 2013 21:35
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29101

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