The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

Sun, H., Tonks, N. K. (November 1994) The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends in Biochemical Sciences, 19 (11). pp. 480-485. ISSN 0968-0004

URL: http://www.ncbi.nlm.nih.gov/pubmed/7855891
DOI: 10.1016/0968-0004(94)90134-1

Abstract

The levels of tyrosine phosphorylation required for cell growth and differentiation are achieved through the coordinated action of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Depending upon the cellular context, these two types of enzymes may either antagonize or cooperate with each other during the signal transmission process. An imbalance between these enzymes may impair normal cell growth, leading to cellular transformation. Both PTKs and PTPs have evolved to a level of structural diversity that allows them to regulate many cellular processes. This review will focus on several specific examples that highlight the interplay between PTPs and PTKs in cell signaling.

Item Type: Paper
Uncontrolled Keywords: IMMEDIATE-EARLY GENE RECEPTOR-BETA MOTH-EATEN PHOSPHORYLATION TRANSFORMATION OVEREXPRESSION PP60(C-SRC) EXPRESSION ACTIVATION MUTATIONS
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > immediate early genes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: November 1994
Date Deposited: 18 Dec 2013 15:21
Last Modified: 18 Dec 2013 15:21
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29065

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