Protein tyrosine phosphatases in signal transduction

Neel, B. G., Tonks, N. K. (1997) Protein tyrosine phosphatases in signal transduction. Current Opinion in Cell Biology, 9 (2). pp. 193-204. ISSN 0955-0674

URL: http://www.ncbi.nlm.nih.gov/pubmed/9069265
DOI: 10.1016/s0955-0674(97)80063-4

Abstract

Protein-tyrosyl phosphorylation, regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key cellular control mechanism. Until recently, little was known about PTPs. However, the past two years have witnessed an explosion of information about PTP structure, regulation and function. Crystal structures of several PTPs have provided insights into enzymatic mechanisms and regulation and suggested the design of 'substrate-trapping' mutants. Candidate homophilic and heterophilic ligands for transmembrane PTPs have been identified, and roles for transmembrane PTPs in regulating cell-cell interactions have been suggested. Finally, progress has been made in understanding signaling by Sro homology 2 domain containing PTPs and PTPs controlling yeast osmoregulatory pathways.

Item Type: Paper
Uncontrolled Keywords: HEMATOPOIETIC-CELL PHOSPHATASE MAP KINASE FISSION YEAST NEGATIVE REGULATION CRYSTAL-STRUCTURE RECEPTOR INSULIN DOMAIN ACTIVATION CD22
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
biotechnology > chromatography > protein purification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
Investigative techniques and equipment > x ray crystallography
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date Deposited: 18 Dec 2013 15:39
Last Modified: 18 Dec 2013 15:39
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29040

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