Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo

Bianchi, C., Sellke, F. W., Del Vecchio, R. L., Tonks, N. K., Neel, B. G. (April 1999) Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo. Experimental Cell Research, 248 (1). pp. 329-338. ISSN 0014-4827

URL: http://www.ncbi.nlm.nih.gov/pubmed/10094839
DOI: 10.1006/excr.1999.4428

Abstract

We investigated the localization of receptor-type protein-tyrosine phosphatase mu (RPTP mu) in tissues by immunofluorescence. RPTP mu immunoreactivity was found almost exclusively within vascular endothelial cells. RPTP mu was more abundant in the arterial tree than in the venous circulation. This pattern of expression was opposite to that of the von Willebrand factor and demonstrated a lack of difference in expression of VE-cadherin. RPTP mu was undetectable in the endocardium, In agreement with previous work on nonendothelial cell lines, RPTP mu was exclusively at the lateral aspects of endothelial cells in vivo and at cell-cell contacts as well as ex vivo in two- or three-dimensional endothelial cell cultures, and expression levels were upregulated by cell density. RPTP mu was detected in few other cells: bronchial and biliary epithelia and cardiocytes (intercalated discs). Our results identify RPTP mu as a new marker of endothelial cell heterogeneity and suggest a possible role in endothelial-specific functions, involving cell-cell contact. (C) 1999 Academic Press.

Item Type: Paper
Uncontrolled Keywords: signal transduction angiogenesis tyrosyl phosphorylation contact inhibition cell junctions PTP-MU CELLS KINASE PHOSPHORYLATION VASCULOGENESIS MEMBER FAMILY SYSTEM TIE-2 TEK
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelial progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelial progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelial progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell > endothelial progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell > endothelial progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell > endothelial progenitor cell

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: April 1999
Date Deposited: 18 Dec 2013 17:12
Last Modified: 18 Dec 2013 17:12
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29028

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving