Combinatorial control of the specificity of protein tyrosine phosphatases

Tonks, N. K., Neel, B. G. (April 2001) Combinatorial control of the specificity of protein tyrosine phosphatases. Current Opinion in Cell Biology, 13 (2). pp. 182-195. ISSN 0955-0674

URL: http://www.ncbi.nlm.nih.gov/pubmed/11248552
DOI: 10.1016/s0955-0674(00)00196-4

Abstract

Protein tyrosine phosphatases (PTPs), the enzymes that dephosphorylate tyrosyl phosphoproteins, were initially believed to be few in number and serve a 'housekeeping' role in signal transduction. Recent work indicates that this is totally incorrect. Instead, PTPs comprise a large superfamily whose members play critical roles in a wide variety of cellular processes. Moreover, PTPs exhibit exquisite substrate specificity in vivo. Recent evidence has led us to propose that members of the PTP family achieve selectivity through different combinations of specific targeting strategies and intrinsic catalytic domain specificity.

Item Type: Paper
Uncontrolled Keywords: GROWTH-FACTOR RECEPTOR NUCLEOTIDE EXCHANGE FACTOR CELL SIGNAL-TRANSDUCTION CRYSTAL-STRUCTURE INSULIN-RECEPTOR MAP-KINASE MYOTUBULAR MYOPATHY TUMOR-SUPPRESSOR MICE LACKING PTP-ALPHA
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > Mitogen-activated protein kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: April 2001
Date Deposited: 18 Dec 2013 19:31
Last Modified: 18 Dec 2013 19:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29014

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