Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance

Petersen, M., Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, B., Nielsen, H. B., Lacy, M., Austin, M. J., Parker, J. E., Sharma, S. B., Klessig, D. F., Martienssen, R., Mattsson, O., Jensen, A. B., Mundy, J. (December 2000) Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance. Cell, 103 (7). pp. 1111-1120. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/11163186
DOI: 10.1016/s0092-8674(00)00213-0

Abstract

Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) revels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.

Item Type: Paper
Uncontrolled Keywords: activated protein-kinase salicylic-acid induction programmed cell-death signal-transduction disease-resistance defense responses gene-expression transcription factors pr-1 gene tobacco
Subjects: organism description > plant > Arabidopsis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
organism description > plant
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: December 2000
Date Deposited: 12 Dec 2013 20:32
Last Modified: 12 Dec 2013 20:32
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28999

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