ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis

Byrne, M. E., Simorowski, J., Martienssen, R. A. (April 2002) ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis. Development, 129 (8). pp. 1957-1965. ISSN 0950-1991

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URL: http://www.ncbi.nlm.nih.gov/pubmed/11934861

Abstract

The shoot apical meristem comprises undifferentiated stem cells and their derivatives, which include founder cells for lateral organs such as leaves. Meristem maintenance and lateral organ specification are regulated in part by negative interactions between the myb domain transcription factor ASYMMETRIC LEAVES1, which is expressed in lateral organ primordia, and homeobox transcription factors which are expressed in the shoot apical meristem (knox genes). The knox gene SHOOT MERISTEMLESS (STAT) negatively regulates ASYMMETRIC LEAVES1 (AS1) which, in turn, negatively, regulates other knox genes including KNAT1 and KNAT2, and positively regulates the novel gene LATERAL ORGAN BOUNDARIES (LOB). Genetic interactions with a second gene, ASYMMETRIC LEAVES2 (AS2), indicate it acts at the same position in this hierarchy as AS1. We have used a second-site suppressor screen to isolate mutations in KNAT1 and we show that KNAT1 is partially redundant with STM in regulating stem cell function. Mutations in KNAT2 show no such interaction. We discuss the regulation and evolution of redundancy among knox genes.

Item Type: Paper
Uncontrolled Keywords: TALE class homeobox shoot apical meristem boundary leaf shape KNAT1 KNAT2 maize homeobox gene shoot apical meristem mads-box genes homeodomain proteins lateral organs knotted class expression thaliana plants maintenance
Subjects: organism description > plant > Arabidopsis
organs, tissues, organelles, cell types and functions > tissues types and functions > apical meristem
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organism description > plant
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: April 2002
Date Deposited: 13 Dec 2013 15:58
Last Modified: 13 Dec 2013 15:58
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28969

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