Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

Byrne, M. E., Barley, R., Curtis, M., Arroyo, J. M., Dunham, M., Hudson, A., Martienssen, R. A. (December 2000) Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis. Nature, 408 (6815). pp. 967-971. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/11140682

Abstract

Meristem function in plants requires both the maintenance of stem cells and the specification of founder cells from which lateral organs arise. Lateral organs are patterned along proximodistal, dorsoventral and mediolateral axes(1,2). Here we show that the Arabidopsis mutant asymmetric leaves(1) (as1) disrupts this process. AS1 encodes a myb domain protein, closely related to PHANTASTICA in Antirrhinum and ROUGH SHEATH2 in maize, both of which negatively regulate knotted-class homeobox genes. AS1 negatively regulates the homeobox genes KNAT1 and KNAT2 and is, in turn, negatively regulated by the meristematic homeobox gene SHOOT MERISTEMLESS. This genetic pathway defines a mechanism for differentiating between stem cells and organ founder cells within the shoot apical meristem and demonstrates that genes expressed in organ primordia interact with meristematic genes to regulate shoot morphogenesis.

Item Type: Paper
Uncontrolled Keywords: shoot apical meristem rough sheath2 gene homeobox gene thaliana plants dorsoventrality phantastica antirrhinum expression trap
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organs, tissues, organelles, cell types and functions > tissues types and functions > apical meristem
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells

organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: December 2000
Date Deposited: 13 Dec 2013 16:31
Last Modified: 13 Dec 2013 16:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28968

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