Integration of the olfactory code across dendritic claws of single mushroom body neurons

Gruntman, E., Turner, G. C. (2013) Integration of the olfactory code across dendritic claws of single mushroom body neurons. Nature Neuroscience, 16 (12). pp. 1821-1829. ISSN 10976256

URL: http://www.ncbi.nlm.nih.gov/pubmed/24141312
DOI: 10.1038/nn.3547

Abstract

In the olfactory system, sensory inputs are arranged in different glomerular channels, which respond in combinatorial ensembles to the various chemical features of an odor. We investigated where and how this combinatorial code is read out deeper in the brain. We exploited the unique morphology of neurons in the Drosophila mushroom body, which receive input on large dendritic claws. Imaging odor responses of these dendritic claws revealed that input channels with distinct odor tuning converge on individual mushroom body neurons. We determined how these inputs interact to drive the cell to spike threshold using intracellular recordings to examine mushroom body responses to optogenetically controlled input. Our results provide an elegant explanation for the characteristic selectivity of mushroom body neurons: these cells receive different types of input and require those inputs to be coactive to spike. These results establish the mushroom body as an important site of integration in the fly olfactory system.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal behavior > olfactory
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Turner lab
Watson School > Publications
Depositing User: Matt Covey
Date Deposited: 11 Nov 2013 21:01
Last Modified: 23 Dec 2014 21:02
PMCID: PMC3908930
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28855

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving