Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery

Zhu, J. J., Malinow, R. (2002) Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery. Nature Neuroscience, 5 (6). pp. 513-514. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11967548
DOI: 10.1038/nn0602-850

Abstract

Anatomical and electrophysiological experiments1, 2, 3, 4, 5, 6 show that central excitatory synapses initially display NMDA (N-methyl-d-aspartate) receptors (NMDARs) and subsequently mature by acquiring AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs). NMDAR activation can lead to rapid synaptic delivery of AMPARs ('AMPAfication')7, 8, but the view that AMPAfication during development requires NMDAR activation has been challenged by studies showing that chronic removal of NMDAR function (either genetically9, 10 or pharmacologically11, 12, 13, 14) has no apparent effect on acquisition of AMPAR-mediated synaptic transmission. Here we show that NMDARs are crucial in the developmental acquisition of AMPAR-mediated synaptic transmission, and that chronic disabling of NMDAR function triggers compensatory mechanisms for NMDAR-independent AMPAfication.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date Deposited: 16 Oct 2013 16:37
Last Modified: 16 Oct 2013 16:37
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28822

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