Geometry and structural plasticity of synaptic connectivity

Stepanyants, A., Hof, P. R., Chklovskii, D. B. (April 2002) Geometry and structural plasticity of synaptic connectivity. Neuron, 34 (2). pp. 275-288. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/11970869
DOI: 10.1016/S0896-6273(02)00652-9

Abstract

Changes in synaptic connectivity patterns through the formation and elimination of dendritic spines may contribute to structural plasticity in the brain. We characterize this contribution quantitatively by estimating the number of different synaptic connectivity patterns attainable without major arbor remodeling. This number depends on the ratio of the synapses on a dendrite to the axons that pass within a spine length of that dendrite. We call this ratio the filling fraction and calculate it from geometrical analysis and anatomical data. The filling fraction is 0.26 in mouse neocortex, 0.22–0.34 in rat hippocampus. In the macaque visual cortex, the filling fraction increases by a factor of 1.6–1.8 from area V1 to areas V2, V4, and 7a. Since the filling fraction is much smaller than 1, spine remodeling can make a large contribution to structural plasticity.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Chklovskii lab
Depositing User: Matt Covey
Date: April 2002
Date Deposited: 30 Oct 2013 20:15
Last Modified: 30 Oct 2013 20:15
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28794

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