Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

Sin, W. C., Haas, K., Ruthazer, E. S., Cline, H. T. (October 2002) Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature, 419 (6906). pp. 475-480. ISSN 0028-0836

Abstract

Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton. Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organism description > animal > Frog > xenopus
CSHL Authors:	Cline, Hollis T. Haas, Kurt Ruthazer, Edward S. Sin, Wun Chey
Communities:	CSHL labs > Cline lab
Depositing User:	Matt Covey
Date:	October 2002
Date Deposited:	31 Oct 2013 16:54
Last Modified:	31 Oct 2013 16:54
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/28788

Actions (login required)

Administrator's edit/view item