Structure and function of dendritic spines

Nimchinsky, E. A., Sabatini, B. L., Svoboda, K. (2002) Structure and function of dendritic spines. Annual Review of Physiology, 64. pp. 313-353. ISSN 0066-4278

URL: http://www.ncbi.nlm.nih.gov/pubmed/11826272
DOI: 10.1146/annurev.physiol.64.081501.160008

Abstract

Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be modulated by sensory experience. Studies of compartmentalization have shown that spines serve primarily as biochemical, rather than electrical, compartments. In particular, recent work has highlighted that spines are highly specialized compartments for rapid large-amplitude Ca(2+) signals underlying the induction of synaptic plasticity.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Matt Covey
Date: 2002
Date Deposited: 08 Jan 2014 14:53
Last Modified: 08 Jan 2014 14:53
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28757

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving