AMPA receptor trafficking and synaptic plasticity

Malinow, R., Malenka, R. C. (March 2002) AMPA receptor trafficking and synaptic plasticity. Annual Review of Neuroscience, 25. pp. 103-126. ISSN 0147-006X

URL: http://www.ncbi.nlm.nih.gov/pubmed/12052905
DOI: 10.1146/annurev.neuro.25.112701.142758

Abstract

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: March 2002
Date Deposited: 08 Jan 2014 16:30
Last Modified: 08 Jan 2014 16:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28743

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