Activity-dependent mapping in the retinotectal projection

Debski, E. A., Cline, H. T. (February 2002) Activity-dependent mapping in the retinotectal projection. Current Opinion in Neurobiology, 12 (1). pp. 93-99. ISSN 0959-4388

URL: http://www.ncbi.nlm.nih.gov/pubmed/11861170
DOI: 10.1016/S0959-4388(02)00295-7

Abstract

It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > brain derived neurotrophic factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: February 2002
Date Deposited: 08 Jan 2014 21:50
Last Modified: 08 Jan 2014 21:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28694

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