Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia

Braus, D. F., Ende, G., Weber-Fahr, W., Demirakca, T., Tost, H., Henn, F. A. (April 2002) Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia. Eur Neuropsychopharmacol, 12 (2). pp. 145-52. ISSN 0924-977X (Print)0924-977X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11872332
DOI: 10.1016/S0924-977X(02)00003-2

Abstract

Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with typical neuroleptics, the other with atypical medications. 1H MR-spectroscopic imaging of the anterior cingulate gyrus was performed in all patients. Perseveration errors in the Wisconsin Card Sorting Test (WCST) served as an additional marker for cingulate gyrus function. Our results showed that N-acetylaspartate (NAA), a measure of neuronal function, was closely correlated with perseveration errors seen on the WCST. Patients treated with atypical medications had fewer errors on the WCST and higher NAA levels than those on typical medications, and there was a correlation between the time treated with atypical medication, higher NAA levels and better test performance. These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner.

Item Type: Paper
Uncontrolled Keywords: Adult Antipsychotic Agents/ pharmacology/ therapeutic use Aspartic Acid/ analogs & derivatives/metabolism Cell Survival/drug effects/physiology Chronic Disease Cross-Sectional Studies Female Gyrus Cinguli/ cytology/ drug effects/metabolism Humans Magnetic Resonance Spectroscopy/statistics & numerical data Male Neurons/cytology/ drug effects/metabolism Neuropsychological Tests/statistics & numerical data Schizophrenia/diagnosis/ drug therapy/metabolism/ pathology
Subjects: diseases & disorders > mental disorders > schizophrenia
Investigative techniques and equipment > spectroscopy > magnetic resonance spectroscopy
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: April 2002
Date Deposited: 08 Jan 2014 22:10
Last Modified: 08 Jan 2014 22:10
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28676

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