Subunit-specific NMDA receptor trafficking to synapses

Barria, A., Malinow, R. (July 2002) Subunit-specific NMDA receptor trafficking to synapses. Neuron, 35 (2). pp. 345-353. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/12160751
DOI: 10.1016/S0896-6273(02)00776-

Abstract

To elucidate mechanisms controlling the number and subunit composition of synaptic NMDA-Rs in hippocampal slice neurons, the NR1, NR2A, and NR2B subunits were optically and electrophysiologically tagged. The NR2 subunit directs delivery of receptors to synapses with different rules controlling NR2A and NR2B. Synaptic incorporation of NR2B-containing receptors is not limited by synaptic transmission nor enhanced by increased subunit expression. NR2A-containing receptors whose expression normally increases with age replace synaptic NR2B-containing receptors. Replacement is enhanced by increased NR2A expression and requires synaptic activity. Surprisingly, spontaneously released transmitter acting on synaptic NMDA-Rs is sufficient for replacement and reduces NMDA-R responses. Thus, as with AMPA-Rs, synaptic trafficking of NMDA-Rs is tightly regulated and has subunit-specific rules with functionally important consequences.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: July 2002
Date Deposited: 09 Jan 2014 15:24
Last Modified: 09 Jan 2014 15:24
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28667

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