Long non-coding RNAs: modulators of nuclear structure and function

Bergmann, Jan H., Spector, David L. (2014) Long non-coding RNAs: modulators of nuclear structure and function. Current Opinion in Cell Biology, 26. pp. 10-18. ISSN 0955-0674

URL: http://www.ncbi.nlm.nih.gov/pubmed/24529241
DOI: 10.1016/j.ceb.2013.08.005

Abstract

Long non-coding (lnc)RNAs are emerging key factors in the regulation of various cellular processes. In the nucleus, these include the organization of nuclear sub-structures, the alteration of chromatin state, and the regulation of gene expression through the interaction with effector proteins and modulation of their activity. Collectively, lncRNAs form the core of attractive models explaining aspects of structural and dynamic regulation in the nucleus across time and space. Here we review recent studies that characterize the molecular function of a subset of these molecules in the regulation and fine-tuning of nuclear state.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > ncRNA
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 25 Sep 2013 15:39
Last Modified: 29 Jan 2015 21:10
PMCID: PMC3927160
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28625

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