The differential requirement of mushroom body α/β subdivisions in long-term memory retrieval in Drosophila

Huang, C., Wang, P., Xie, Z., Wang, L., Zhong, Y. (July 2013) The differential requirement of mushroom body α/β subdivisions in long-term memory retrieval in Drosophila. Protein and Cell, 4 (7). pp. 512-519. ISSN 1674800X

URL: http://www.ncbi.nlm.nih.gov/pubmed/23722532
DOI: 10.1007/s13238-013-3035-8

Abstract

The mushroom body (MB), a bilateral brain structure possessing about 2000-2500 neurons per hemisphere, plays a central role in olfactory learning and memory in Drosophila melanogaster. Extensive studies have demonstrated that three major types of MB neurons (α/β, α′/β′ and Γ) exhibit distinct functions in memory processing, including the critical role of approximately 1000 MB α/β neurons in retrieving long-term memory. Inspired by recent findings that MB α/β neurons can be further divided into three subdivisions (surface, posterior and core) and wherein the α/β core neurons play an permissive role in long-term memory consolidation, we examined the functional differences of all the three morphological subdivisions of MB α/β by temporally precise manipulation of their synaptic outputs during long-term memory retrieval. We found the normal neurotransmission from a combination of MB α/β surface and posterior neurons is necessary for retrieving both aversive and appetitive long-term memory, whereas output from MB α/β posterior or core subdivision alone is dispensable. These results imply a specific requirement of about 500 MB α/β neurons in supporting long-term memory retrieval and a further functional partitioning for memory processing within the MB α/β region. © 2013 Higher Education Press and Springer-Verlag Berlin Heidelberg.

Item Type: Paper
Uncontrolled Keywords: appetitive olfactory conditioning aversive olfactory conditioning memory retrieval mushroom body neural circuits
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: Matt Covey
Date: July 2013
Date Deposited: 16 Aug 2013 19:10
Last Modified: 16 Aug 2013 19:10
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28540

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