Principles and concepts of DNA replication in bacteria, archaea, and eukarya

O'Donnell, M., Langston, L., Stillman, B. (2013) Principles and concepts of DNA replication in bacteria, archaea, and eukarya. Cold Spring Harbor Perspectives in Biology, 5 (7). ISSN 19430264

URL: http://www.ncbi.nlm.nih.gov/pubmed/23818497
DOI: 10.1101/cshperspect.a010108

Abstract

The accurate copying of genetic information in the double helix of DNA is essential for inheritance of traits that define the phenotype of cells and the organism. The core machineries that copy DNA are conserved in all three domains of life: bacteria, archaea, and eukaryotes. This article outlines the general nature of the DNA replication machinery, but also points out important and key differences. The most complex organisms, eukaryotes, have to coordinate the initiation of DNA replication from many origins in each genome and impose regulation that maintains genomic integrity, not only for the sake of each cell, but for the organism as a whole. In addition, DNA replication in eukaryotes needs to be coordinated with inheritance of chromatin, developmental patterning of tissues, and cell division to ensure that the genome replicates once per cell division cycle.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organism description > bacteria
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: Matt Covey
Date Deposited: 19 Jul 2013 16:18
Last Modified: 20 Jun 2017 16:24
PMCID: PMC3685895
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28459

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