Senescent cells spread the word: non-cell autonomous propagation of cellular senescence

Tasdemir, N., Lowe, S. W. (June 2013) Senescent cells spread the word: non-cell autonomous propagation of cellular senescence. Embo Journal, 84 (1). pp. 114-127. ISSN 0261-4189

URL: http://www.ncbi.nlm.nih.gov/pubmed/23778965
DOI: 10.1038/emboj.2013.139

Abstract

Senescence has long been considered a cell autonomous arrest programme restricting the propagation of damaged cells in tissues. Now there is accumulating evidence that senescent cells can communicate with their environment. In a recent report by Gil and colleagues (Acosta et al, 2013), it now seems senescence can be transmitted in a paracrine fashion in several in vitro and in vivo contexts. In addition to broadening our understanding of the biology of senescence, these new findings may have interesting implications for tissue homeostasis and future cancer therapies.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:
Communities: CSHL labs > Lowe lab
Watson School > Publications
Depositing User: Matt Covey
Date: 18 June 2013
Date Deposited: 28 Jun 2013 14:11
Last Modified: 22 Sep 2014 20:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28380

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