Mapping brain circuitry with a light microscope

Osten, P., Margrie, T. W. (2013) Mapping brain circuitry with a light microscope. Nat Methods, 10 (6). pp. 515-23. ISSN 1548-7105 (Electronic)1548-7091 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/23722211
DOI: 10.1038/nmeth.2477

Abstract

The beginning of the 21st century has seen a renaissance in light microscopy and anatomical tract tracing that together are rapidly advancing our understanding of the form and function of neuronal circuits. The introduction of instruments for automated imaging of whole mouse brains, new cell type–specific and trans-synaptic tracers, and computational methods for handling the whole-brain data sets has opened the door to neuroanatomical studies at an unprecedented scale. We present an overview of the present state and future opportunities in charting long-range and local connectivity in the entire mouse brain and in linking brain circuits to function.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
Investigative techniques and equipment > microscopy > flourescence microscopy
organs, tissues, organelles, cell types and functions > organs types and functions
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matt Covey
Date Deposited: 24 Jun 2013 20:38
Last Modified: 24 Jun 2013 20:38
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28366

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving