Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination

Znamenskiy, P., Zador, A. M. (2013) Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination. Nature, 497. pp. 482-485. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/23636333
DOI: 10.1038/nature12077

Abstract

The neural pathways by which information about the acoustic world reaches the auditory cortex are well characterized, but how auditory representations are transformed into motor commands is not known. Here we use a perceptual decision-making task in rats to study this transformation. We demonstrate the role of corticostriatal projection neurons in auditory decisions by manipulating the activity of these neurons in rats performing an auditory frequency-discrimination task. Targeted channelrhodopsin-2 (ChR2)-mediated stimulation of corticostriatal neurons during the task biased decisions in the direction predicted by the frequency tuning of the stimulated neurons, whereas archaerhodopsin-3 (Arch)-mediated inactivation biased decisions in the opposite direction. Striatal projections are widespread in cortex and may provide a general mechanism for the control of motor decisions by sensory cortex.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons

organism description > animal behavior > decision making
CSHL Authors:
Communities: CSHL labs > Zador lab
Watson School > Publications
Depositing User: Matt Covey
Date Deposited: 23 May 2013 15:43
Last Modified: 23 Sep 2014 13:51
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28326

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