Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., Agarwala, R., Ainscough, R., Alexandersson, M., An, P., Antonarakis, S. E., Attwood, J., Baertsch, R., Bailey, J., Barlow, K., Beck, S., Berry, E., Birren, B., Bloom, T., Bork, P., Botcherby, M., Bray, N., Brent, M. R., Brown, D. G., Brown, S. D., Bult, C., Burton, J., Butler, J., Campbell, R. D., Carninci, P., Cawley, S., Chiaromonte, F., Chinwalla, A. T., Church, D. M., Clamp, M., Clee, C., Collins, F. S., Cook, L. L., Copley, R. R., Coulson, A., Couronne, O., Cuff, J., Curwen, V., Cutts, T., Daly, M., David, R., Davies, J., Delehaunty, K. D., Deri, J., Dermitzakis, E. T., Dewey, C., Dickens, N. J., Diekhans, M., Dodge, S., Dubchak, I., Dunn, D. M., Eddy, S. R., Elnitski, L., Emes, R. D., Eswara, P., Eyras, E., Felsenfeld, A., Fewell, G. A., Flicek, P., Foley, K., Frankel, W. N., Fulton, L. A., Fulton, R. S., Furey, T. S., Gage, D., Gibbs, R. A., Glusman, G., Gnerre, S., Goldman, N., Goodstadt, L., Grafham, D., Graves, T. A., Green, E. D., Gregory, S., Guigó, R., Guyer, M., Hardison, R. C., Haussler, D., Hayashizaki, Y., LaHillier, D. W., Hinrichs, A., Hlavina, W., Holzer, T., Hsu, F., Hua, A., Hubbard, T., Hunt, A., Jackson, I., Jaffe, D. B., Johnson, L. S., Jones, M., Jones, T. A., Joy, A., Kamal, M., Karlsson, E. K. (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420 (6915). pp. 520-562. ISSN 00280836 (ISSN)
Abstract
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Polymorphism Biodiversity Genes Immunology Proteins Genetic engineering genome rodent article comparative gene mapping gene cluster genetic analysis genetic polymorphism genetic variability human nonhuman priority journal quality control quantitative trait locus sequence analysis sequence homology synteny Animals Base Composition Chromosomes, Mammalian Conserved Sequence CpG Islands Evolution, Molecular Gene Expression Regulation Genome, Human Genomics Humans Mice Mice, Knockout Mice, Transgenic Models, Animal Multigene Family Mutagenesis Neoplasms Physical Chromosome Mapping Proteome Pseudogenes Quantitative Trait Loci Repetitive Sequences, Nucleic Acid RNA, Untranslated Selection (Genetics) Sequence Analysis, DNA Sex Chromosomes Species Specificity Variation (Genetics) Rodentia |
| Subjects: | bioinformatics > genomics and proteomics > alignment bioinformatics > genomics and proteomics > analysis and processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > McCombie lab |
| Depositing User: | Matt Covey |
| Date: | 2002 |
| Date Deposited: | 25 Apr 2013 14:09 |
| Last Modified: | 25 Apr 2013 14:09 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28229 |
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