Model for a robust neural integrator

Koulakov, A. A., Raghavachari, S., Kepecs, A., Lisman, J. E. (2002) Model for a robust neural integrator. Nature Neuroscience, 5 (8). pp. 775-782. ISSN 10976256 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/12134153
DOI: 10.1038/nn893

Abstract

Integrator circuits in the brain show persistent firing that reflects the sum of previous excitatory and inhibitory inputs from external sources. Integrator circuits have been implicated in parametric working memory, decision making and motor control. Previous work has shown that stable integrator function can be achieved by an excitatory recurrent neural circuit, provided synaptic strengths are tuned with extreme precision (better than 1% accuracy). Here we show that integrator circuits can function without fine tuning if the neuronal units have bistable properties. Two specific mechanisms of bistability are analyzed, one based on local recurrent excitation, and the other on the voltage-dependence of the NMDA (N-methyl-D-aspartate) channel. Neither circuit requires fine tuning to perform robust integration, and the latter actually exploits the variability of neuronal conductances.

Item Type: Paper
Uncontrolled Keywords: n methyl dextro aspartic acid accuracy article cell membrane potential channel gating excitation memory motor control nerve cell network nerve conduction priority journal synapse Computer Simulation Models, Neurological Neural Networks (Computer) Neurons Receptors, N-Methyl-D-Aspartate Reproducibility of Results
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Kepecs lab
CSHL labs > Koulakov lab
Depositing User: Matt Covey
Date Deposited: 10 Apr 2013 20:19
Last Modified: 22 Jul 2015 20:23
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28116

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