Location-dependent differences between somatic and dendritic IPSPs

Lengyel, M., Kepecs, Á, Érdi, P. (1999) Location-dependent differences between somatic and dendritic IPSPs. Neurocomputing, 26-27. pp. 193-197. ISSN 09252312 (ISSN)

URL: http://www.sciencedirect.com/science/article/pii/S...
DOI: 10.1016/s0925-2312(99)00081-8

Abstract

Recent experimental evidence suggests that inhibitory synapses are associated with different actions depending upon their location (Miles et al., Neuron 16 (1996) 815-823). We investigated that question of whether this effect is due to different subspecies of GABA(A) receptors giving rise to distinct responses (Pearce, Neuron 10 (1993) 189-20) or cable filtering by the dendritic tree. The effects of electrotonic filtering on GABA(A) receptor mediated IPSPs were studied in hippocampal pyramidal cells. We implemented two models with different morphologies where these differences could be explained by electrotonic filtering alone. Our parameter search resulted in realistic passive cell models where the dependence of electrotonic attenuation on morphological distance agreed with that seen in reconstructed cells. Recent experimental evidence suggests that inhibitory synapses are associated with different actions depending upon their location (Miles et al., Neuron 16 (1996) 815-823). We investigated that question of whether this effect is due to different subspecies of GABAA receptors giving rise to distinct responses (Pearce, Neuron 10 (1993) 189-20) or cable filtering by the dendritic tree. The effects of electrotonic filtering on GABAA receptor mediated IPSPs were studied in hippocampal pyramidal cells. We implemented two models with different morphologies where these differences could be explained by electrotonic filtering alone. Our parameter search resulted in realistic passive cell models where the dependence of electrotonic attenuation on morphological distance agreed with that seen in reconstructed cells.

Item Type: Paper
Uncontrolled Keywords: Cable filtering Inhibition Multi-compartmental methods Bioelectric potentials Cells Mathematical models Mathematical morphology Multi compartmental methods Brain 4 aminobutyric acid receptor action potential article artificial neural network compartment model computer simulation digital filtering inhibitory postsynaptic potential mathematical parameters priority journal pyramidal nerve cell
Subjects: Investigative techniques and equipment > electrophysiology
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Kepecs lab
Depositing User: Matt Covey
Date: 1999
Date Deposited: 10 Apr 2013 20:17
Last Modified: 10 Apr 2013 20:17
URI: http://repository.cshl.edu/id/eprint/28115

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