An adaptive spike-timing-dependent plasticity rule

Tegnér, J., Kepecs, A. (2002) An adaptive spike-timing-dependent plasticity rule. Neurocomputing, 44-46. pp. 189-194. ISSN 09252312 (ISSN)

URL: http://www.sciencedirect.com/science/article/pii/S...
DOI: 10.1016/s0925-2312(02)00393-4

Abstract

We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations. © 2002 Published by Elsevier Science B.V.

Item Type: Paper
Uncontrolled Keywords: Hebbian Homeostatic mechanisms Learning Spike correlations Calcium Computer simulation Perturbation techniques Plasticity Post-synaptic firing rates Neurology action potential article biophysics calcium transport controlled study nerve cell plasticity postsynaptic potential presynaptic potential priority journal spike wave synapse
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
organism description > animal behavior > learning
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Kepecs lab
Depositing User: Matt Covey
Date Deposited: 10 Apr 2013 20:27
Last Modified: 10 Apr 2013 20:27
URI: http://repository.cshl.edu/id/eprint/28110

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