Rap2-JNK removes synaptic AMPA receptors during depotentiation

Zhu, Y., Pak, D., Qin, Y., McCormack, S. G., Kim, M. J., Baumgart, J. P., Velamoor, V., Auberson, Y. P., Osten, P., Van Aelst, L., Sheng, M., Zhu, J. J. (2005) Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron, 46 (6). pp. 905-916. ISSN 08966273 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15953419
DOI: 10.1016/j.neuron.2005.04.037

Abstract

The related small GTPases Ras and Rap1 are important for signaling synaptic AMPA receptor (-R) trafficking during long-term potentiation (LTP) and long-term depression (LTD), respectively. Rap2, which shares 60% identity to Rap1, is present at excitatory synapses, but its functional role is unknown. Here, we report that Rap2 activity, stimulated by NR2A-containing NMDA-R activation, depresses AMPA-R-mediated synaptic transmission via activation of JNK rather than Erk1/2 or p38 MAPK. Moreover, Rap2 controls synaptic removal of AMPA-Rs with long cytoplasmic termini during depotentiation. Thus, Rap2-JNK pathway, which opposes the action of the NR2A-containing NMDA-R-stimulated Ras-ERK1/2 signaling and complements the NR2B-containing NMDA-R-stimulated Rap1-p38 MAPK signaling, channels the specific signaling for depotentiating central synapses. Copyright ©2005 by Elsevier Inc.

Item Type: Paper
Uncontrolled Keywords: AMPA receptor guanosine triphosphatase mitogen activated protein kinase 1 mitogen activated protein kinase 3 Rap protein stress activated protein kinase animal cell animal tissue article controlled study cytoplasm enzyme activation enzyme activity hippocampus long term potentiation nerve cell plasticity nonhuman priority journal rat signal transduction synaptic potential alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Animals Animals, Newborn Blotting, Western Cells, Cultured Drug Interactions Electric Stimulation Enzyme Inhibitors Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Fluorescent Antibody Technique Gene Expression Regulation Green Fluorescent Proteins JNK Mitogen-Activated Protein Kinases Long-Term Depression (Physiology) Magnesium Models, Neurological Mutagenesis N-Methylaspartate Neurons Patch-Clamp Techniques Phosphorylation rap GTP-Binding Proteins Rats Receptors, AMPA Recombinant Proteins Synaptic Transmission Time Factors Transfection Valine
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation

organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Osten lab
CSHL labs > Van Aelst lab
Depositing User: Matt Covey
Date: 2005
Date Deposited: 05 Apr 2013 02:03
Last Modified: 22 Feb 2017 20:11
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28101

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