Spatial coherence and stationarity of local field potentials in an isolated whole hippocampal preparation in vitro

Gillis, J. A., Zhang, L., Skinner, F. K. (2010) Spatial coherence and stationarity of local field potentials in an isolated whole hippocampal preparation in vitro. Journal of Computational Neuroscience, 29 (3). pp. 521-532. ISSN 09295313 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/20082133
DOI: 10.1007/s10827-009-0207-x

Abstract

Local field potential (LFP) multielectrode recordings of spontaneous rhythms in an isolated whole hippocampal preparation are characterized with respect to their spatial variability within the hippocampus, and their frequency properties. Using simulated data, we categorize potential relationships between frequency variation over time in LFP recordings and spatial variability between electrodes. We then use data recorded from the intact preparation to distinguish between our theoretical categories. We find that the LFP recordings have a close to spatially invariant frequency distribution (not phase) across the hippocampus, and differ in frequency only in a component that may be seen as physiological noise. From these facts, we conclude that the isolated hippocampal LFP recordings represent a single signal and may be regarded as a unitary circuitry. We additionally examine phase differences across our recording sites. We use our characterization of the hippocampal isolate's properties to predict its spatial coherence in response to high frequency stimulation. We find that there is a finely tuned inverse relationship between temporal variability in the hippocampal isolate's LFP recordings and their spatial coherence. © Springer Science+Business Media, LLC 2010.

Item Type: Paper
Uncontrolled Keywords: Hippocampus Local field potential Multielectrode Spontaneous rhythm Time-frequency animal tissue article controlled study electrode in vitro study mouse nerve cell membrane potential neurophysiology noise nonhuman priority journal signal noise ratio signal processing spatial variability spatial variation temporal variability Animals CA1 Region, Hippocampal CA3 Region, Hippocampal Data Interpretation, Statistical Electrodes Electrophysiological Phenomena Evoked Potentials Extracellular Space Mice Nerve Net Neurons Signal Processing, Computer-Assisted
Subjects: Investigative techniques and equipment
Investigative techniques and equipment > electrophysiology
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Gillis Lab
Depositing User: Matt Covey
Date Deposited: 04 Apr 2013 13:56
Last Modified: 04 Apr 2013 13:56
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28087

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