Glutamatergic plasticity by synaptic delivery of GluR-B-long-containing AMPA receptors

Kolleker, A., Zhu, J. J., Schupp, B. J., Qin, Y., Mack, V., Borchardt, T., Kohr, G., Malinow, R., Seeburg, P. H., Osten, P. (2003) Glutamatergic plasticity by synaptic delivery of GluR-B-long-containing AMPA receptors. Neuron, 40 (6). pp. 1199-1212. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/14687553
DOI: 10.1016/S0896-6273(03)00722-0

Abstract

Activity-driven delivery of AMPA receptors is proposed to mediate glutamatergic synaptic plasticity, both during development and learning. In hippocampal CA1 principal neurons, such trafficking is primarily mediated by the abundant GluR-A subunit. We now report a study of GluR-B-long, a C-terminal splice variant of the GluR-B subunit. GluR-Blong synaptic delivery is regulated by two forms of activity. Spontaneous synaptic activity-driven GluR-Blong transport maintains one-third of the steady-state AMPA receptor-mediated responses, while GluR-Blong delivery following the induction of LTP is responsible for approximately 50% of the resulting potentiation at the hippocampal CA3 to CA1 synapses at the time of GIuR-B-long peak expression-the second postnatal week. Trafficking of GluR-B-long-containing receptors thus mediates a GluR-A-independent form of glutamatergic synaptic plasticity in the juvenile hippocampus.

Item Type: Paper
Uncontrolled Keywords: TRAFFICKING SUBUNIT PERMEABILITY POTENTIATION SYNAPSES NEURONS GENE LTP IDENTIFICATION INTERNEURONS
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Osten lab
CSHL labs > Malinow lab
Depositing User: Matt Covey
Date Deposited: 27 Mar 2013 16:34
Last Modified: 27 Mar 2013 16:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28023

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving