Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts

Schumann, G., Rujescu, D., Kissling, C., Soyka, M., Dahmen, N., Preuss, U. W., Wieman, S., Depner, M., Wellek, S., Lascorz, J., Bondy, B., Giegling, I., Anghelescu, I., Cowen, M. S., Poustka, A., Spanagel, R., Mann, K., Henn, F. A., Szegedi, A. (December 2003) Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biol Psychiatry, 54 (12). pp. 1422-6. ISSN 0006-3223 (Print)0006-3223 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/14675807
DOI: 10.1016/S0006-3223(03)00635-8

Abstract

BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice. METHODS: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples. RESULTS: In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5' untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5'-UTR region but not with the remaining SNPs. CONCLUSIONS: Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele.

Item Type: Paper
Uncontrolled Keywords: 5' Untranslated Regions/genetics Adult Alanine/genetics Alcoholism/ genetics/metabolism Case-Control Studies Chi-Square Distribution Cohort Studies Cysteine/genetics Female Gene Frequency Genetic Variation Genotype Glycine/genetics Humans Male Middle Aged Polymorphism, Single Nucleotide Proto-Oncogene Proteins/ genetics/metabolism Proto-Oncogene Proteins c-fyn Threonine/genetics
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 December 2003
Date Deposited: 27 Mar 2013 15:53
Last Modified: 27 Mar 2013 15:53
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28020

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