Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain

Schmitt, A., May, B., Muller, B., Jatzko, A., Petroianu, G., Braus, D. F., Henn, F. A. (November 2003) Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain. Pharmacopsychiatry, 36 (6). pp. 292-6. ISSN 0176-3679 (Print)0176-3679 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/14663653
DOI: 10.1055/s-2003-45116

Abstract

BACKGROUND: Alterations in AMPA and kainate receptor binding have been revealed in post-mortem schizophrenic brains. As most patients had been treated with antipsychotics, medication effects cannot be excluded as a possible explanation for these results. METHODS: Within the framework of this animal study, we investigated [3H]AMPA and [3H]kainate receptor binding in different rat brain regions following 6 months of oral treatment with either haloperidol (1.5 mg/kg/day) or clozapine (45 mg/kg/day). RESULTS: AMPA receptor binding was increased after haloperidol treatment in the striatum, nucleus accumbens, cingulate cortex, and insular cortex. Clozapine showed increased AMPA receptor binding only in the anterior cingulate cortex. Kainate receptor binding was increased by both drugs in all hippocampal subfields. CONCLUSIONS: This altered receptor binding may be related to beneficial neuroleptic effects and side effects. Furthermore, neuroleptic therapy may contribute to some of the post-mortem findings in the striatum in schizophrenia.

Item Type: Paper
Uncontrolled Keywords: Animals Antipsychotic Agents/pharmacology Autoradiography Brain/ drug effects/metabolism Clozapine/ pharmacology Dopamine Antagonists/ pharmacology GABA Antagonists/pharmacology Haloperidol/ pharmacology Male Rats Rats, Sprague-Dawley Receptors, AMPA/ drug effects/metabolism Receptors, Kainic Acid/ drug effects/metabolism Serotonin Antagonists/ pharmacology Up-Regulation
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
diseases & disorders > mental disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > animal
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > organs types and functions
organs, tissues, organelles, cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: November 2003
Date Deposited: 27 Mar 2013 15:46
Last Modified: 27 Mar 2013 15:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28017

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